Product Detail
Product NameSTAT2(Ab-690) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
ApplicationsWB IHC
Species ReactivityHu
SpecificityThe antibody detects endogenous level of total STAT2 protein.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around aa.688~692 (R-K-Y-L-K) derived from Human STAT2.
Target NameSTAT2
ConjugateUnconjugated
Other NamesP113; ISGF-3; STAT113
Accession NoSwiss-Prot: P52630
NCBI Protein: NP_005410.1
Uniprot
P52630
Gene ID
6773;
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Predicted MW: 113kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Western blot analysis of extracts from Hela cells using STAT2(Ab-690) Antibody #21536 and the same antibody preincubated with blocking peptide.
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using STAT2(Ab-690) Antibody #21536(left) or the same antibody preincubated with blocking peptide(right).
STAT2 encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus.
Fu, X. et al. (1992) Biochemistry 89, 7840-7843.
Park, C. et al. (2000) Immunity 13, 795-804.
Horvath, C. et al. (1996) Molecular and Cellular Biology 16, 6957-6964.
Improta, T. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 4776-4780.
If you have published an article using product 21536, please notify us so that we can cite your literature.
et al,Expression of interferon effector gene SART1 correlates with interferon treatment response against hepatitis B infection. In Mediators Inflamm on 2016 by Yong Li, Chuanlong Zhu et al..PMID: 28077916
, (2016),
PMID:
28077916
et al,CMTM4 promotes PD-L1-mediated macrophage apoptosis by enhancing STAT2 phosphorylation in sepsis.
, (2025),
PMID:
40122504
Yes
