Product Detail
Product NameTau Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide
ApplicationsWB
Species ReactivityHu Ms Rt
SpecificityThe antibody detects endogenous level of total Tau protein.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around aa. 725-729(T-G-S-I-D) derived from Rat Tau
Target NameTau
ConjugateUnconjugated
Other NamesMAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau
Accession NoSwiss-Prot: P19332
NCBI Protein: NP_058908.2
Uniprot
P19332
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Predicted MW: 48 62 78kd
Western blotting: 1:500~1:1000
Western blot analysis of extract from rat brain and mouse brain tissue using TAU Antibody #21570
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Johnson , G.V. and Stoothoff , W.H. (2004) J. Cell Sci. 117, 5721-5729.
Hanger, D. P. et al. (1998) J. Neurochem. 71, 2465-2476.
Bramblett, G. T. et al. (1993) Neuron 10, 1089-1099.
If you have published an article using product 21570, please notify us so that we can cite your literature.
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