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GluR1 Antibody#21575

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Product Detail

Product NameGluR1 Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

ApplicationsWB

Species ReactivityHu Ms Rt

SpecificityThe antibody detects endogenous levels of total GluR1 protein.

Immunogen TypePeptide-KLH

Immunogen DescPeptide sequence around aa. 831~835 (K-S-R-S-E) derived from Human GluR1

Target NameGluR1

ConjugateUnconjugated

Other NamesGLR1; GLUH1; GRIA1; GluR-1; GluR-A

Accession NoSwiss-Prot: P42261
NCBI Protein: NP_000818.2

Uniprot P42261

Gene ID 2890;

Concentration1.0mg/ml

FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details
Predicted MW: 110kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from mouse brain and using GluR1 Antibody #21575.
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of a-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Emamian ES, et al. (2004) J Neurosci. 24(7): 1561-4
Palmer, C.L. et al. (2005) Pharmacol. Rev. 57, 253-277.

If you have published an article using product 21575, please notify us so that we can cite your literature.

et al,Acid-sensing Ion Channel 1a Is Required for mGlu Receptor Dependent Long-Term Depression in the Hippocampus.In Pharmacol Res on 2017 May by D Mango, E Braksator,et al..PMID: 28137639 , (2017),
PMID: 28137639

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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