Product Detail
Product NameBeclin-1 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
ApplicationsWB
Species ReactivityHu
SpecificityThe antibody detects endogenous level of total Beclin-1 protein.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around aa.69-73( F-I-E-T-P) derived from Human Beclin-1.
Target NameBeclin-1
ConjugateUnconjugated
Other NamesATG6; VPS30;
Accession NoSwiss-Prot: Q14457
NCBI Protein: NP_003757.1
Uniprot
Q14457
Gene ID
8678;
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Predicted MW: 60kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from Raji and K562 cells using Beclin-1 Antibody #21582.
Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.
Sagona A.P., Nezis I.P., Pedersen N.M., Liestol K., Poulton J., Rusten T.E., Skotheim R.I., Raiborg C., Stenmark H.Nat. Cell Biol. 12:362-371(2010)
Sun Q., Fan W., Chen K., Ding X., Chen S., Zhong Q.Proc. Natl. Acad. Sci. U.S.A. 105:19211-19216(2008)
If you have published an article using product 21582, please notify us so that we can cite your literature.
et al,PIWI-Interacting RNA-004800 Is Regulated by S1P Receptor Signaling Pathway to Keep Myeloma Cell Survival.In Front Oncol on 2020 Apr 15 by Ma H, Wang H, et al..PMID: 32351883
, (2020),
PMID:
32351883
et al,Ulva Pertusa Lectin 1 Delivery Through Adenovirus Vector Affects Multiple Signaling Pathways in Cancer Cells.In Glycoconj J on 2017 Aug by Gongchu Li , Zhenzhen Zhao,et al..PMID: 28349379
, (2017),
PMID:
28349379
Yes
