Product Detail
Product NameERAB Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
ApplicationsWB
Species ReactivityHu
SpecificityThe antibody detects endogenous level of total ERAB protein.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around aa.253~257(L-D-G-A-I)derived from Human ERAB.
Target NameERAB
ConjugateUnconjugated
Other NamesABAD; CAMR; HCD2; MHBD; HADH2
Accession NoSwiss-Prot: Q99714
NCBI Protein: NP_004484.1
Uniprot
Q99714
Gene ID
3028;
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Predicted MW: 27kd
Western blotting: 1:500~1:1000
Western blot analysis of extract from JK, HUVEC, HepG2 and Hela cells using ERAB Antibody #21602
Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).
Holzmann J., Frank P., Loeffler E., Bennett K.L., Gerner C., Rossmanith W. Cell 135:462-474(2008)
If you have published an article using product 21602, please notify us so that we can cite your literature.
Yes
