Product Detail
Product NameMBP(myelin basic protein) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
ApplicationsWB
Species ReactivityHu Ms Rt
SpecificityThe antibody detects endogenous level of total MBP(myelin basic protein) protein.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around aa.291~295(G-G-R-D-S
Target NameMBP(myelin basic protein)
ConjugateUnconjugated
Other NamesMGC99675
Accession NoSwiss-Prot: P02686
NCBI Protein: NP_001020252.1
Uniprot
P02686
Gene ID
4155;
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Predicted MW: 14~33kd
Western blotting: 1:500~1:1000
Western blot analysis of extract from Rat brain, Mouse brain and Rat hippocampus Tissue using MBP Antibody #21640
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
Pribyl T.M., Campagnoni C.W., Kampf K. Proc. Natl. Acad. Sci. U.S.A. 90:10695-10699(1993)
Nye S.H., Pelfrey C.M., Burkwit J.J. Mol. Immunol. 32:1131-1141(1995)
If you have published an article using product 21640, please notify us so that we can cite your literature.
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