Product Detail
Product NameAdiponectin Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
ApplicationsWB
Species ReactivityHu Ms Rt
SpecificityThe antibody detects endogenous level of total Adiponectin protein.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around aa.235~239(T-G-F-L-L) derived from Human Adiponectin.
Target NameAdiponectin
ConjugateUnconjugated
Other NamesACDC; ADPN; APM1
Accession NoSwiss-Prot: Q15848
NCBI Protein: NP_001171271.1
Uniprot
Q15848
Gene ID
9370;
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Predicted MW: 27kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from Rat and Mouse brain tissue using Adiponectin Antibody #21665.
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-a by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Yamauchi T., Kamon J., Waki H. Kadowaki T.Nat. Med. 7:941-946(2001)
Richards A.A., Stephens T., Charlton H.K. Mol. Endocrinol. 20:1673-1687(2006)
If you have published an article using product 21665, please notify us so that we can cite your literature.
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