Product Detail
Product NameC/EBPb Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
ApplicationsWB
Species ReactivityHu
SpecificityThe antibody detects endogenous levels of total C/EBPb protein.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around aa.336~340(E-P-L-L-A) derived from Human C/EBPb.
Target NameC/EBPb
ConjugateUnconjugated
Other NamesIL6DBP; CRP2; TCF5; LAP; NF-IL6
Accession NoSwiss-Prot: P17676
NCBI Protein: NP_005185.2
Uniprot
P17676
Gene ID
1051;
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Predicted MW: 36kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from Rat brain, Mouse brain tissue and 293 cells using C/EBPb Antibody #21675.
Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation
Buck M., Poli V., Hunter T., Chojkier M. Mol. Cell 8:807-816(2001)
Gauci S., Helbig A.O., Slijper M., Krijgsveld J. Mohammed S.Anal. Chem. 81:4493-4501(2009)
If you have published an article using product 21675, please notify us so that we can cite your literature.
et al,Clock represses preadipocytes adipogenesis via GILZ .In J Cell Physiol.On 2018 Aug by Zhu Z, Xu L et al..PMID: 29278648
, (2018),
PMID:
29278648
Yes
