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ABCA1 Antibody#21676

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Product Detail

Product NameABCA1 Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

ApplicationsWB

Species ReactivityHu Ms Rt

SpecificityThe antibody detects endogenous level of total ABCA1 protein.

Immunogen TypePeptide-KLH

Immunogen DescPeptide sequence around aa.2253~2257(D-E-K-V-K) derived from Human ABCA1.

Target NameABCA1

ConjugateUnconjugated

Other NamesTGD; ABC1; CERP; ABC-1;

Accession NoSwiss-Prot: O95477
NCBI Protein: NP_005493.2

Uniprot O95477

Gene ID 19;

Concentration1.0mg/ml

FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details
Predicted MW: 254kd
Western blotting: 1:500~1:1000
Western blot analysis of extract from Raw264.7 cells using ABCA1 Antibody #21676
cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.

Kaplan R., Gan X., Menke J.G. Lipid Res. 43:952-959(2002)
Hamon Y., Trompier D., Ma Z., Venegas V. PLoS ONE 1:E120-E120(2006)
Singaraja R.R., Kang M.H., Vaid K. Berthiaume L. Res. 105:138-147(2009)

If you have published an article using product 21676, please notify us so that we can cite your literature.

et al,Chronic Administration of Mitochondrion-Targeted Peptide SS-31 Prevents Atherosclerotic Development in ApoE Knockout Mice Fed Western Diet.In PLoS One on 2017 Sep 29 by Meng Zhang , Hongting Zhao,et al..PMID: 28961281 , (2017),
PMID: 28961281
et al,Pioglitazone reduces lipid droplets in cholesterolosis of the gallbladder by increasing ABCA1 and NCEH1 expression.In Mol Cell Biochem on 2015 Jan by Jing-Min Wang , Dong Wang et al..PMID:25280398 , (2015),
PMID: 25280398
et al,22 (R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPAR纬鈥揕XR伪鈥揂BCA1 pathway in cholesterosis of the gallbladder.In Biochem Biophys Res Commun on 2014 Apr 25 by Jing-Min Wang, Dong Wang et al..PMID:24704452 , (2014),
PMID: 24704452
et al,Quercetin Regulates Hepatic Cholesterol Metabolism by Promoting Cholesterol-To-Bile Acid Conversion and Cholesterol Efflux in Rats.In Nutr Res on 2016 Mar by Min Zhang , Zongkai Xie et al..PMID:26923514 , (2016),
PMID: 26923514
et al,Iron together with lipid downregulates protein levels of ceruloplasmin in macrophages associated with rapid foam cell formation.In J Atheroscler Thromb on 2016 Oct 1 by Qi Wang , Jiajie Ji et al..PMID: 27040361 , (2016),
PMID: 27040361
et al,Mitochondrion-Targeted Peptide SS-31 Inhibited Oxidized Low-Density Lipoproteins-Induced Foam Cell Formation through both ROS Scavenging and Inhibition of Cholesterol Influx in RAW264.7 Cells.In Molecules on 2015 Dec 1 by Shuangying Hao, Jiajie Ji et al..PMID: 26633327 , (2015),
PMID: 26633327
et al,5-HT2A Receptor and 5-HT Degradation Play a Crucial Role in Atherosclerosis by Modulating Macrophage Foam Cell Formation, Vascular Endothelial Cell Inflammation, and Hepatic Steatosis In J Atheroscler Thromb on 2022 Mar 1 by Yingying Ma, Xiurui Liang,et al..PMID: 33536397 , (2022),
PMID: 33536397
More
et al,Drug metabolism-related gene ABCA1 augments temozolomide chemoresistance and immune infiltration abundance of M2 macrophages in gliomaInEur J Med ResOn2023 Sep 25byYuanliang Yan?#?1,?Yuanhong Liu et al..PMID:?37749600 , (2023),
PMID: 37749600
et al,Niacin-induced lysosomal free cholesterol efflux via LXRα-mediated signaling pathways in macrophages retards the progression of atherosclerosis , (2025),
PMID:

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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