Product Detail
Product NameCytochrome C Antibody
Host SpeciesRabbit
ClonalityPolyclonal
ApplicationsWB
Species ReactivityHu Ms Rt
SpecificityThe antibody detects endogenous level of total Cytochrome C protein.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around aa.71-75(N-P-K-K-Y) derived from Human Cytochrome C.
Target NameCytochrome C
ConjugateUnconjugated
Other NamesCYC, HCS, THC4,
Accession NoSwiss-Prot:P99999
Gene ID:54205
Uniprot
P99999
Gene ID
54205;
Concentration1.0mg/ml
Application Details
Predicted MW: 14kd
Western blotting: 1: 500~1: 1000
Western blot analysis of extracts from 3T3, C6 and A549 cells using Cytochrome C Antibody #21680.
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
If you have published an article using product 21680, please notify us so that we can cite your literature.
et al,The role of InsulIn-like growth factor 1 In ALS cell and mouse models: A mitochondrial protector. In BraIn Res Bull on 2019 Jan by Wen D, Cui C et al..PMID:30414993
, (2019),
PMID:
30414993
et al,PDZRN3 protects against apoptosis in myoblasts by maintaining cyclin A2 expression.In Sci Rep on 2020 Jan 24; by Honda T, Inui M. et al..PMID:31980707
, (2020),
PMID:
31980707
et al,PDZRN3 protects against apoptosis in myoblasts by maintaining cyclin A2 expression.In Sci Rep on 2020 Jan 24; by Honda T, Inui M. et al..PMID:31980707
, (2020),
PMID:
31980707
et al,BAD overexpression inhibits cell growth and induces apoptosis via mitochondrial-dependent pathway in non-small cell lung cancer.In Cancer Cell Int on 2013 Jun 1 by Jiang L, Luo M, et al..PMID:23725574
, (2013),
PMID:
23725574
et al,Apoptosis sensitization by Euphorbia factor L1 in ABCB1-mediated multidrug resistant K562/ADR cells. In Molecules on 2013 Oct 16 by Tao Yi, Yi-Na Tang, et al..PMID:
24135937
, (2013),
PMID:
24135937
et al, Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway.In Am J Cancer Res on 2016 Mar 15 by Jian-Ye Zhang, Min-Ting Lin et al..PMID: 27186433
, (2016),
PMID:
27186433
et al,Combinational treatment of curcumin and quercetin against gastric cancer MGC-803 cells in vitro Molecules on 2015 Jun 22 by Jian-Ye Zhang , Min-Ting Lin et al..PMID:26111180
, (2015),
PMID:
26111180
More
et al,L-carnitine alleviates synovitis in knee osteoarthritis by regulating lipid accumulation and mitochondrial function through the AMPK-ACC-CPT1 signaling pathway InJ Orthop Surg ResOn2023 May 26byTaiyang Liao , Wei Mei et al..PMID:37237380
, (2023),
PMID: 37237380
Yes
