Product Detail
Product NameSmad1/Smad5/Smad8 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
ApplicationsWB
Species ReactivityHu Ms Rt
SpecificityThe antibody detects endogenous level of total Smad1, Smad5, Smad8 protein.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around aa.461-465(I-S-S-V-S) derived from Human Smad1. This sequence has the same homology in Smad5 and Smad8.
Target NameSmad1/Smad5/Smad8
ConjugateUnconjugated
Other Names Mad-related protein 1, SMAD 1, hSMAD1, Transforming growth factor-beta-signaling protein 1,
Accession NoSwiss-Prot:Q15797
Gene ID:4086
Uniprot
Q15797
Gene ID
4086;
Concentration1.0mg/ml
Application Details
Predicted MW: 60kd
Western blotting: 1: 500~1: 1000
Western blot analysis of extracts from 3T3 cells using Smad1/Smad5/Smad8 Antibody #21684.
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).SMAD5 is a receptor-regulated SMAD (R-SMAD). SMAD9 is a receptor-regulated SMAD (R-SMAD). Has been shown to be activated by activin type I receptor-like kinases (ALK-2, ALK-3, ALK-6) which stimulate heteromerization between SMAD9 and SMAD4. May play a role in osteoblast differentiation and maturation.
If you have published an article using product 21684, please notify us so that we can cite your literature.
et al,Inhibition of TGF尾 signaling decreases osteogenic differentiation of fibrodysplasia ossificans progressiva fibroblasts in a novel in vitro model of the disease.In Bone.On 2016 Mar by Micha D, Voermans E et al..PMID:26769004
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PMID:
26769004
et al,Vital Roles of Gremlin-1 in Pulmonary Arterial Hypertension Induced by Systemic-to-Pulmonary Shunts. In J Am Heart Assoc on 2020 Aug 4 by Liukun
Meng, Xiao Teng, et al..PMID: 32750294
, (2020),
PMID:
32750294
et al,Hepatoprotective and neuroprotective effects of quinacrine against bile duct ligation-induced hepatic encephalopathy in rats: Role of bone morphogenetic proteins signaling. In Life Sci on 2024 Nov 12 by Manar M Esmail, Noha M Saeed,et al..PMID:39537098
, (2024),
PMID:
39537098
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