Product Detail
Product NameKHK Isoform A Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
ApplicationsWB IHC
Species ReactivityHu
SpecificityThe antibody detects endogenous level of total KHK Isoform A protein.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around aa.90~95 (T-T-G-S-V) derived from Human KHK Isoform A .
ConjugateUnconjugated
Other NamesKetohexokinase; Hepatic fructokinase; KHK
Accession NoSwiss-Prot#: P50053-2
NCBI Gene ID: 3795
NCBI Protein#: NP_000212.1
Uniprot
P50053
Gene ID
3795;
Calculated MW33kd
Concentration1.0mg/mL
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C
Application Details
Western blotting: 1:500-1000
Immunohistochemistry: 1:50~1:100
Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.
Bonthron D.T., Brady N., Donaldson I.A., Steinmann B.Hum. Mol. Genet. 3:1627-1631(1994)
If you have published an article using product 21708, please notify us so that we can cite your literature.
et al,A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation
, (2016 May),
PMID:
27088854
et al,Prognostic Impact of Metabolism ReprogrammIng Markers Acetyl-CoA Synthetase 2 Phosphorylation and KetohexokInase-A Expression In Non-Small-Cell Lung CarcInoma. In Front Oncol on 2019 Nov 5 by Yang X, Shao F, et al..PMID:31750240
, (2019),
PMID:
31750240
et al,A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation.In Nat Cell Biol on 2016 Ma by Xinjian Li , Xu Qian et al..PMID:27088854
, (2016),
PMID:
27088854
et al,The small intestine shields the liver from fructose-induced steatosis. In Nat Metab on 2020 Jul by Cholsoon Jang, Shogo Wada, et al..PMID: 32694791
, (2020),
PMID:
32694791
et al,Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer. In Nat Commun on 2020 Oct 28 by Jiyoung Kim, Jengmin Kang, et al..PMID:33116123
, (2020),
PMID:
33116123
et al,Increased ketohexokinase-A governs fructose-induced podocyte hypertrophy by IL-6/STAT3 signaling activation
, (2020),
PMID:
et al,Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction. In Cell Metab on 2020 Jul 7
by Ana Andres-Hernando, David J Orlicky, et al..PMID:32502381
, (2020),
PMID:
32502381
More
et al,Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis. In JHEP Rep on 2020 Nov 20 by Emma L Shepherd, Raquel Saborano, et al..PMID:33490936
, (2021),
PMID: 33490936
et al,IL-6/STAT3 signaling activation exacerbates high fructose-induced podocyte hypertrophy by ketohexokinase-A-mediated tristetraprolin down-regulation. In Cell Signal on 2021 Oct by Jie Zhou, Jie Yang,et al..PMID:34252535
, (2021),
PMID: 34252535
et al,The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62
, (2019),
PMID: 31032410
et al,Dietary fructose improves intestinal cell survival and nutrient absorption
, (2021),
PMID: 34408323
The lead time is currently 1 week.
