Product Detail
Product NameChitotriosidase antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationPurified by antigen-affinity chromatography.
ApplicationsWB
Species ReactivityHu
Immunogen TypeRecombinant protein
Immunogen DescRecombinant protein fragment contain a sequence corresponding to a region within amino acids 216 and 433 of Chitotriosidase
Target NameChitotriosidase
ConjugateUnconjugated
Accession NoSwiss-Prot:Q13231
Gene ID:1118
Uniprot
Q13231
Gene ID
1118;
Concentration1mg/ml
FormulationSupplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
StorageStore at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.
Application Details
Predicted MW: 52kd
Western blotting: 1:500-1:3000
Sample (30 ug of whole cell lysate)
A: Hela
10% SDS PAGE
Primary antibody diluted at 1: 1000
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. [provided by RefSeq]
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