Product Detail
Product NameTRPM2 antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationPurified by antigen-affinity chromatography.
ApplicationsWB IHC
Species ReactivityHu
Immunogen TypeRecombinant protein
Immunogen DescRecombinant protein fragment contain a sequence corresponding to a region within amino acids 181 and 393 of TRPM2
Target NameTRPM2
ConjugateUnconjugated
Accession NoSwiss-Prot:O94759
Gene ID:7226
Uniprot
O94759
Gene ID
7226;
Concentration1.2mg/ml
FormulationSupplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
StorageStore at -20˚C for long term preservation (recommended). Store at 4˚C for short term use.
Application Details
Predicted MW: 171kd
Western blotting: 1:500-1:3000
Immunohistochemistry: 1:100-1:500
Sample (30 ug of whole cell lysate)
A: Hep G2
7.5% SDS PAGE
Primary antibody diluted at 1: 500
Immunohistochemical analysis of paraffin-embedded MDAMB468 xenograft, using TRPM2 antibody at 1: 100 dilution.
The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq]
If you have published an article using product 22689, please notify us so that we can cite your literature.
et al,TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet’s disease
, (2024),
PMID:
Yes
