Product Detail
Product NameTRAF6 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationIon exchange chromatography purified
ApplicationsELISA WB ICC
Species ReactivityHu Ms Rt
Immunogen TypePeptide
Immunogen DescRaised against a peptide corresponding to 14 amino acids near the C-terminus of human TRAF6.
Target NameTRAF6
ConjugateUnconjugated
Accession NoSwiss-Prot:Q9Y4K3
Gene ID:7189
Uniprot
Q9Y4K3
Gene ID
7189;
Concentration1mg/ml
FormulationSupplied in PBS containing 0.02% sodium azide.
StorageCan be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Application Details
Western blot analysis of TRAF6 in PC-3 cell lysates with TRAF6 antibody at 1 ug/mL in the presence (A) or absence (B) of 1 ug blocking peptide.
Immunocytochemistry of TRAF6 in K562 cells with TRAF6 antibody at 0.5 ug/mL.
Signals from the IL-1 receptor (IL-1R)/Toll-like receptor (TLR) and TNF receptor (TNFR) superfamilies are critical for regulating the function of antigen-presenting cells. Signals transduced by these molecules lead to increased expression and activation of transcription factors such as NF-κB. TNF receptor-associated factor 6 (TRAF6) is unique in that it is a signaling adapter molecule common to both families. TRAF6 is important in cytokine production, dendritic cell (DC) maturation, and the T cell stimulatory capacity of DCs in response to TLR and CD40 ligands. It can be activated in the IL-1R/TLR signaling pathway by IL-1 receptor-associated kinase 1 (IRAK-1) or by other TLR adaptor molecules such as TRIF. Also, it has been shown that TRAF6 can interact directly with TNFR family members CD40 and RANK.
If you have published an article using product 24191, please notify us so that we can cite your literature.
et al,Classical prescription Daqinjiao decoction inhibit cerebral ischemia/reperfusion induced necroptosis and ferroptosis through multiple mechanisms.
, (2025),
PMID:
39736347
Yes
