Product Detail
Product NameTLR4 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationTLR4 Antibody is affinity chromatography purified via peptide column.
ApplicationsELISA WB ICC
Species ReactivityHu
Immunogen TypePeptide
Immunogen DescRaised against a peptide corresponding to 15 amino acids near the amino-terminus of human TLR4.
Target NameTLR4
ConjugateUnconjugated
Accession NoSwiss-Prot:O00206
Gene ID:7099
Uniprot
O00206
Gene ID
7099;
Concentration1mg/ml
FormulationSupplied in PBS containing 0.02% sodium azide.
StorageCan be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Application Details
Immunocytochemistry of TLR4 in K562 cells with TLR4 antibody at 2 ug/mL.
Western blot analysis of TLR4 in human small intestine lysate with TLR4 antibody at (A) 2 and (B) 4 μg/mL.
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-κB. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.
If you have published an article using product 24194, please notify us so that we can cite your literature.
et al,Phthalide derivative CD21 attenuates tissue plasminogen activator-induced hemorrhagic transformation in ischemic stroke by enhancing macrophage scavenger receptor 1-mediated DAMP (peroxiredoxin 1) clearance
, (2021),
PMID:
34162400
Yes
