Product Detail
Product NameTEM2 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAffinity chromatography purified via peptide column
ApplicationsELISA WB IHC
Species ReactivityHu Ms Rt
Immunogen TypePeptide
Immunogen DescRaised against a 15 amino acid peptide near the carboxy terminus of the human TEM2.
Target NameTEM2
ConjugateUnconjugated
Other NamesTumor endothelial marker 2, Ras homolog enriched in striatum, Rhes, RASD2
Accession NoQ96D21
Uniprot
Q96D21
Gene ID
23551;
Concentration1mg/ml
FormulationSupplied in PBS containing 0.02% sodium azide.
StorageCan be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Application Details
Western blot analysis of TEM2 in human colon tissue lysate with TEM2 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of TEM2 in human colon tissue with TEM2 antibody at 2.5 ug/mL.
Rhes, also known as tumor endothelial marker 2 (TEM2), is a small GTP-binding protein that is predominantly expressed in the striatal region of the brain. This protein belongs to the RASD subfamily of Ras-related GTP-binding protein superfamily and is thought to play a role in the normal development and function of the brain as mice lacking this gene showed increased anxiety levels and motor coordination deficits. Rhes was identified as TEM2 through analysis of genes whose expression was upregulated in tumor endothelium. Tumor endothelial markers are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies.
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et al,The identities of insulin signaling pathway are affected by overexpression of Tau and its phosphorylation form
, (2022),
PMID:
36589543
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