Product Detail
Product NameFOXO1 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAffinity chromatography purified via peptide column
ApplicationsELISA WB ICC
Species ReactivityHu Ms Rt
Immunogen TypePeptide
Immunogen DescRaised against a 15 amino acid peptide near the amino terminus of human FOXO1.
Target NameFOXO1
ConjugateUnconjugated
Other NamesForkhead box O1, FKH1, FKHR, Forkhead in rhabdomyosarcoma, FOXO1A
Accession NoSwiss-Prot:Q12778
Gene ID:2308
Uniprot
Q12778
Gene ID
2308;
Concentration1mg/ml
FormulationSupplied in PBS containing 0.02% sodium azide.
StorageCan be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Application Details
Western blot analysis of FOXO1 in Hela cell lysate with FOXO1 antibody at 1 ug/mL.
Immunocytochemistry of FOXO1 in HeLa cells with FOXO1 antibody at 4 ug/mL.
FOXO1, also known as FKHR or ForkHead in Rhabdomyosarcoma, is a 70 kDa protein which is a ubiquitously expressed member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In insulin-responsive tissues, stress or nutrient abundance triggers phosphorylation by PKB/AKT, blocking nuclear translocation and activity. Genetic mutations involving FOXO1A are a cause of alveolar rhabdomyosarcoma (RMS2). Recent studies link the anti-tumor activity of FOXO1 and the process of autophagy.
If you have published an article using product 25137, please notify us so that we can cite your literature.
et al,Dynamic Impacts of Stock Enhancement on Kaluga Sturgeon (Huso dauricus): Novel Conservation Strategy Insights from the Gut Microbe Composition and Gene Expression Mode.
, (2025),
PMID:
40003945
Yes
