Welcome to Sabbiotech!     
Email:info@signalwayantibody.com
Welcome Login Register My Cart(0,$0.00)
Location： Home > Mouse Monoclonal Antibodies > MyD88 Monoclonal Antibody

MyD88 Monoclonal Antibody#26020

Datasheet PDF
Availability： Yes
Total Amount:$
ADD TO CART
Detail Pictures Description Publish(0) Other
Product Detail

Product NameMyD88 Monoclonal Antibody

Clone No.mAb (Clone 2E9C2)

Host SpeciesMouse

ClonalityMonoclonal

PurificationImmunoaffinity chromotography purified IgG

ApplicationsELISA WB IHC

Species ReactivityHu Ms

Immunogen TypeRecombinant Protein

Immunogen DescRaised against a recombinant protein corresponding to amino acids 176 to 280 of human MyD88.

Target NameMyD88

ConjugateUnconjugated

Other NamesMyD88 (2E9C2): Myeloid differentiation primary response gene 88

Accession NoSwiss-Prot:Q99836
Gene ID:4615

Uniprot Q99836

Gene ID 4615;

Concentration1mg/ml

FormulationSupplied in PBS containing 0.02% sodium azide.

StorageCan be stored at -20˚C, stable for one year.

Application Details
Western blot analysis of MyD88 in EL4 whole cell lysate with MyD88 antibody at 2 ug/mL.

The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-κB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.

If you have published an article using product 26020, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

QUICK NAV

New Products

Cell Signal Transduction

Cancer

Stem Cell

Neuroscience

Help and Support

Contact Us

Terms

Privacy Policy

support

Distributors