Product Detail
Product NameHax1a Monoclonal Antibody
Clone No.mAb (Clone 9G3D11)
Host SpeciesMouse
ClonalityMonoclonal
PurificationImmunoaffinity chromotography purified IgG
ApplicationsELISA WB
Species ReactivityHu Rt
Immunogen TypePeptide
Immunogen DescRaised against a 15 amino acid peptide near the amino terminus of human Hax1a.
Target NameHax1a
ConjugateUnconjugated
Other NamesHax1a (9G3D11), HS-1 associated protein X-1, HCLS1 associated protein X-1, HCLSBP1, HS1BP1
Accession NoSwiss-Prot:O00165
Gene ID:10456
Uniprot
O00165
Gene ID
10456;
Concentration1mg/ml
FormulationSupplied in PBS containing 0.02% sodium azide.
StorageCan be stored at -20˚C, stable for one year.
Application Details
Western blot analysis of Hax1a in human brain tissue lysate with Hax1a antibody at (A) 1 and (B) 2 ug/mL.
The HS-1 associated protein X-1 (Hax1) was initially identified in a yeast two-hybrid assay on the basis of its ability to bind to the hemapoietic cell-specific protein 1 (HS-1). Hax1 possesses anti-apoptotic activity and is structurally related to Bcl-2 family members, including the presence of BH1- and BH2-like domains. It has recently been shown to interact with HIV viral protein R (Vpr), a protein required for viral pathogenesis of HIV and linked to T-cell apoptosis through activation of caspases 3 and 9. Other studies indicate that Hax1-mediated processing of HtrA2 (also known as Omi) by the mitochondrial protease PARL allows survival of lymphocytes and neurons when cytokines are limiting. At least four isoforms of Hax1 are known to exist. This antibody is expected to recognize the longest isoform (Hax1a) as well as the shortest.
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