Product Detail
                                
                                                                        Product NameBim Monoclonal Antibody
                                        Clone No.mAb (Clone 1C2H4)
                                         Host SpeciesMouse
                                         ClonalityMonoclonal
                                                                                PurificationImmunoaffinity chromotography purified IgG
                                        ApplicationsELISA WB ICC
                                        Species ReactivityHu Ms Rt
                                                                                Immunogen TypeRecombinant protein
                                         Immunogen DescRaised against  a recombinant protein corresponding to amino acids 2 to 198 of human Bim.
                                         Target NameBim 
                                         ConjugateUnconjugated
                                                                                 Other NamesBim (1C2H4): Bcl-2 interacting protein, Bcl-2-related ovarian death gene, BOD, Bcl-2-like 11
                                        Accession NoSwiss-Prot:O43521
Gene ID:10018
                                        Uniprot
                                        O43521
                                        
                                        Gene ID
                                        10018;
                                        
                                                                                                                        Concentration1mg/ml
                                         FormulationSupplied in PBS containing 0.02% sodium azide.
                                        StorageCan be stored at -20˚C, stable for one year.
                                                                                                                                                         
                                Application Details
                                
                             
                            
                                                                
                                    
                                    Western blot analysis of 5 ng of Bim recombinant protein with Bim antibody at 1 ug/mL.
                                 
                                                                
                                    
                                    Immunocytochemistry of Bim in K562 cells with Bim antibody at 10 ug/mL.
                                 
                                                             
                            
                                Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim is another BH3 domain containing protein which can induce apoptosis. Bim interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.
                            
                            
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