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Location： Home > Mouse Monoclonal Antibodies > Her2 Monoclonal Antibody

Her2 Monoclonal Antibody #27150

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Product Detail

Product NameHer2 Monoclonal Antibody

Host SpeciesMouse

ClonalityMonoclonal

PurificationAffinity-chromatography

ApplicationsELISA WB IHC

Species ReactivityHu

SpecificityHer2 antibody detects endogenous levels of total Her2

Immunogen TypeRecombinant protein

Immunogen DescPurified recombinant fragment of human Her2 expressed in E. Coli

Target NameHer2

ConjugateUnconjugated

Other NamesC-erbB-2, EC 2.7.10.1, Epidermal growth factor receptor-related protein, ErbB2, HER2, MLN 19, NEU, NEU proto-oncogene, NGL, Receptor protein-tyrosine kinase erbB-2, Receptor protein-tyrosine kinase erbB-2 precursor, Tyrosine kinase-type cell surface recep

Accession NoSwiss-Prot#: P04626

Uniprot P04626

Gene ID 2064;

Sdspage MW180KD

Concentration1.0mg/ml

FormulationMouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

StorageStore at -20°C/1 year

Application Details
 ELISA: 1:10000
   WB 1:500 - 1:2000
 IHC 1:200 - 1:1000
Western blot analysis using Her2 mouse mAb against SKBR3 (1) and MCF-7 (2) cell lysate.

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

If you have published an article using product 27150, please notify us so that we can cite your literature.

et al,An injectable multimodal thiolated carboxymethyl cellulose hydrogel for advanced gastric cancer treatment. , (2025),
PMID: 40020807

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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