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Location： Home > Mouse Monoclonal Antibodies > GRB2 Monoclonal Antibody

GRB2 Monoclonal Antibody#27180

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Product Detail

Product NameGRB2 Monoclonal Antibody

Clone No.3B2-G2-E5

Host SpeciesMouse

ClonalityMonoclonal

IsotypeIgG1

ApplicationsWB

Species ReactivityHu Rt Ms Mk

SpecificityThis antibody detects endogenous levels of GRB2 and does not cross-react with related proteins.

Immunogen TypeRecombinant Protein

Immunogen DescPurified recombinant human GRB2 protein fragments expressed in E.coli.

Target NameGRB2

ConjugateUnconjugated

Other NamesAbundant SRC homology; Adapter protein GRB2; ASH; Ash protein; EGFRBP GRB2; Epidermal growth factor receptor binding protein; Epidermal growth factor receptor binding protein GRB2; GRB 2; GRB2 adapter protein; Grb2; GRB2_HUMAN; Grb3 3;

Accession NoUniprot: P62993

Gene ID: 2885

Uniprot P62993

Gene ID 2885;

Sdspage MW25kd

FormulationAscites

Storagestore at -20˚C

Application Details

 Western blotting: 1:500

Western blot detection of GRB2 in Jurkat,Raji,PC-12&3T3 cell lysates and using GRB2 antibody(1:500 diluted).Predicted band size: 25KDa Observed band size: 25KDa
Western blot detection of GRB2 in MCF7,3T3,COS7,C6 and Hela cell lysates and using GRB2 antibody(1:300 diluted).Predicted band size: 25KDa.Observed band size: 25KDa.

 Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.

If you have published an article using product 27180, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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