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Location： Home > Mouse Monoclonal Antibodies > TORC1 Monoclonal Antibody

TORC1 Monoclonal Antibody#27183

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Product NameTORC1 Monoclonal Antibody

Clone No.4E7-C1-F9-E6

Host SpeciesMouse

ClonalityMonoclonal

IsotypeIgM

ApplicationsWB ICC

Species ReactivityHu Ms Mk Rt

SpecificityThis antibody detects endogenous levels of CRTC1 and does not cross-react with related proteins.

Immunogen TypeRecombinant Protein

Immunogen DescPurified recombinant human CRTC1 protein fragments expressed in E.coli.

Target NameTORC1

ConjugateUnconjugated

Other NamesKIAA0616; CREB regulated transcription coactivator 1; CREB-regulated transcription coactivator 1; CRTC1; CRTC1_HUMAN; FLJ14027; KIAA0616; MECT 1; Mucoepidermoid carcinoma translocated 1; Mucoepidermoid carcinoma translocated protein 1; TORC-1; TORC1;

Accession NoUniprot: Q6UUV9

Gene ID: 23373

Uniprot Q6UUV9

Gene ID 23373;

Sdspage MW78kd

Formulationascites

Storagestore at -20˚C

Application Details

Western blotting: 1:2000 

Immunocytochemistry: 1:200
Immunocytochemistry staining of HeLa cells fixed with 4% Paraformaldehyde and using anti-CRTC1 antibody (dilution 1:200).
Western blot detection of CRTC1 antibody in Hela,mouse brain,SW480,COS7,C6 and 3T3 cell lysates using CRTC1 antibody (1:2000 diluted).Predicted band size:78KDa.Observed band size:78KDa.

 Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.Acts as a coactivator, in the SIK/TORC signaling pathway,being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation.Enhances the interaction of CREB1 with TAF4.Regulates the expression of specific CREB-activated genes such as the steroidogenic gene,StAR.Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells.Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses.May be required for dendritic growth of developing cortical neurons.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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