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Smad2 Monoclonal Antibody#27195

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Product Detail

Product NameSmad2 Monoclonal Antibody

Clone No.6H5-E3-C11

Host SpeciesMouse

ClonalityMonoclonal

IsotypeIgG1

ApplicationsWB ICC

Species ReactivityHu

SpecificityThis antibody detects endogenous levels of SMAD2 and does not cross-react with related proteins.

Immunogen TypeRecombinant Protein

Immunogen DescPurified recombinant human SMAD2 protein fragments expressed in E.coli.

Target NameSmad2

ConjugateUnconjugated

Other NameshMAD 2; hMAD-2; hSMAD2; JV18 1; JV18; JV18; JV18-1; JV181; MAD; MAD; MAD homolog 2; MAD Related Protein 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; Mothers Against Decapentaplegic Homolog 2; Mothers Against Decapentaplegic Homolog 2;

Accession NoUniprot: Q15796

Gene ID: 4087

Uniprot Q15796

Gene ID 4087;

Sdspage MW60kd

Formulationascites

Storagestore at -20˚C

Application Details

Western blotting: 1:500

Immunocytochemistry: 1:100
Immunocytochemistry staining of HeLa cells fixed with 1% Paraformaldehyde and using anti-SMAD2 antibody (dilution 1:100).
Western blot detection of SMAD2 antibody in Hela,A431,Jurkat and K562 cell lysates using SMAD2 antibody (1:500 diluted).Predicted band size:60KDa.Observed band size:60KDa.

 Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases.Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and,on formation of the SMAD2/SMAD4 complex,activates transcription.May act as a tumor suppressor in colorectal carcinoma.Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

If you have published an article using product 27195, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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