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SIRT1 Polyclonal Antibody#27523

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Product Detail

Product NameSIRT1 Polyclonal Antibody

Host SpeciesRabbit

ClonalityPolyclonal

IsotypeIgG

PurificationAffinity purification

ApplicationsWB,IHC,IF

Species ReactivityHuman,Mouse,Rat

Immunogen DescA synthetic peptide of human SIRT1

ConjugateUnconjugated

Other NamesSIR2;SIR2L1;SIR2alpha;SIRT1;sirtuin 1

Accession NoUniprot:Q96EB6
GeneID:23411

Uniprot Q96EB6

Gene ID 23411

Calculated MW140kDa

Sdspage MW120kDa

FormulationPBS with 0.02% sodium azide,50% glycerol,pH7.3.

StorageStore at -20˚C. Avoid freeze / thaw cycles.

Application Details
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using SIRT1 antibody.
Immunohistochemistry of paraffin-embedded Mouse heart using SIRT1 antibody.
Immunofluorescence analysis of NIH-3T3 cells using SIRT1 antibody.
Immunofluorescence analysis of C6 cells using SIRT1 antibody.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

If you have published an article using product 27523, please notify us so that we can cite your literature.

et al,Fucoidan modulates SIRT1 and NLRP3 to alleviate hypertensive retinopathy: in vivo and in vitro insights. In J Transl Med on 2024 Feb 15 by Jing Li, Xiaochen Wang,et al..PMID:38360728 , (2024),
PMID: 38360728

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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