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PGC1 alpha Polyclonal Antibody#27583

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Product Detail

Product NamePGC1 alpha Polyclonal Antibody

Host SpeciesRabbit

ClonalityPolyclonal

IsotypeIgG

PurificationThe antibody was purified by immunogen affinity chromatography.

ApplicationsWB,IHC,IF

Species ReactivityHuman,Mouse,Rat

Immunogen DescKLH-conjugated synthetic peptide of human PGC1 alpha

ConjugateUnconjugated

Other NamesPPARGC1A;LEM6;PGC-1(alpha);PGC-1alpha;PGC-1v;PGC1;PGC1A;PPARGC1;PPARG coactivator 1 alpha;PGC1 alpha

Accession NoUniprot:Q9UBK2
GeneID:10891

Uniprot Q9UBK2

Gene ID 10891

Calculated MW91KDa

Sdspage MW91KDa

FormulationLiquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol,and 0.01% sodium azide.

StorageStore at -20˚C. Avoid freeze / thaw cycles.

Application Details
WB 1:500 - 1:1000
IHC 1:50 - 1:100
IF 1:50 - 1:100
Western blot analysis of extracts of various cell lines, using PGC1�� antibody.
Immunohistochemistry of paraffin-embedded mouse kidney using PGC1�� Rabbit pAb.
Immunofluorescence analysis of U2OS cells using PGC1�� Rabbit pAb.
Immunohistochemistry of paraffin-embedded rat lung using PGC1�� Rabbit pAb.

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

If you have published an article using product 27583, please notify us so that we can cite your literature.

et al,KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis , (2019),
PMID: 31629659

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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