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COL1A1 Polyclonal Antibody#28307

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Product Detail

Product NameCOL1A1 Polyclonal Antibody

Host SpeciesRabbit

ClonalityPolyclonal

IsotypeIgG

PurificationAffinity purification

ApplicationsWB,IHC,IF

Species ReactivityHuman,Mouse,Rat

Immunogen DescA synthetic peptide of human COL1A1 (NP_000079.2).

ConjugateUnconjugated

Other NamesCOL1A1; EDSC; OI1; OI2; OI3; OI4; collagen alpha-1(I) chain

Accession NoSwiss-Prot#:P02452
NCBI Gene ID:1277

Uniprot P02452

Gene ID 1277;

Calculated MW139kDa

Sdspage MW130-160 kDa，210-250kDa

FormulationAvoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

StorageStore at -20˚C

Application Details
WB 1:500 - 1:1000
IHC 1:50 - 1:200
IF 1:50 - 1:200
IP 1:50 - 1:200
Immunohistochemistry of paraffin-embedded human placenta using COL1A1 at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded rat ovary using COL1A1 at dilution of 1:200 (40x lens).
Western blot analysis of extracts of various cell lines, using COL1A1 at 1:1000 dilution.
Immunofluorescence analysis of rat ovary using COL1A1 at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of human breast cancer using COL1A1 at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of human breast cancer using COL1A1 at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded human colon carcinoma using COL1A1 at dilution of 1:200 (40x lens).
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

If you have published an article using product 28307, please notify us so that we can cite your literature.

et al,Role of the CTRP6/AMPK pathway in kidney fibrosis through the promotion of fatty acid oxidation. In Eur J Pharmacol on 2021 Feb 5 by Yu-Hong Xie, Yi Xiao,et al..PMID:33245899 , (2021),
PMID: 33245899
et al,3D printed PGCL@PLA/10CSPL composite scaffolds loaded with fibronectin 1 for intervertebral disc degeneration treatment, In Biofabrication on 2024 Dec 13 by Weilin Zhang, Siyuan Chen,et al..PMID:39668784 , (2024),
PMID: 39668784

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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