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Location： Home > Polyclonal Antibodies > TLR4 Polyclonal Antibody

TLR4 Polyclonal Antibody#29072

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Product Detail

Product NameTLR4 Polyclonal Antibody

Host SpeciesRabbit

ClonalityPolyclonal

IsotypeIgG

PurificationAffinity purification

ApplicationsWB,IHC,IF

Species ReactivityHuman,Mouse,Rat

Immunogen DescA synthetic peptide of human TLR4 (NP_612564.1).

ConjugateUnconjugated

Other NamesTLR4;ARMD10;CD284;TLR-4;TOLL

Accession NoGeneID:7099
Swiss Prot:O00206

Uniprot O00206

Gene ID 7099;

Calculated MW73kDa/91kDa/95kDa

Sdspage MW110kDa

Concentration1.0mg/ml

FormulationPBS with 0.02% sodium azide,50% glycerol,pH7.3.

StorageStore at -20˚C. Avoid freeze / thaw cycles.|Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.114.

Application Details
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Immunohistochemistry of paraffin-embedded mouse spleen using TLR4 antibody at dilution of 1:100 .
Western blot analysis of extracts of various cell lines, using TLR4 antibody at 1:1000 dilution.
Immunofluorescence analysis of NIH-3T3 cells using TLR4 Polyclonal Antibody at dilution of 1:100 . Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded human appendix using TLR4 antibody at dilution of 1:100 .
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

If you have published an article using product 29072, please notify us so that we can cite your literature.

et al,The Extracts of Angelica sinensis and Cinnamomum cassia from Oriental Medicinal Foods Regulate Inflammatory and Autophagic Pathways against Neural Injury after Ischemic Stroke. In Oxid Med Cell Longev on 2021 Jun 26 by Cheng Luo, Qi Chen,et al..PMID:34257822 , (2021),
PMID: 34257822
et al,Melatonin Attenuates LPS-Induced Proinflammatory Cytokine Response and Lipogenesis in Human Meibomian Gland Epithelial Cells via MAPK/NF-κB Pathway. In Invest Ophthalmol Vis Sci on 2022 May 2 by Ren Liu, Jing Li, et al..PMID:35506935 , (2022),
PMID: 35506935
et al,Combined Administration of Curcumin and Chondroitin Sulfate Alleviates Cartilage Injury and Inflammation via NF-κB Pathway in Knee Osteoarthritis Rats. In Front Pharmacol on 2022 May 19 by Ting Guan, Liu-Gang Ding, et al..PMID: 35662715 , (2022),
PMID: 35662715
et al,Perihematomal Neurovascular Protection: Blocking HSP90 Reduces Blood Infiltration Associated with Inflammatory Effects Following Intracerebral Hemorrhage in Rates. In Transl Stroke Res on 2024 Sep 4 by Di Hu, Chao Yan,et al..PMID:39230786 , (2024),
PMID: 39230786

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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