Product Detail
Product NamePPAR alpha Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB
Species ReactivityMouse
Immunogen DescA synthetic peptide of human PPAR alpha
ConjugateUnconjugated
Other NamesPPARA; NR1C1; PPAR; PPARalpha; hPPAR; peroxisome proliferator-activated receptor alpha
Accession NoSwiss-Prot#:Q07869
NCBI Gene ID:5465
Uniprot
Q07869
Gene ID
5465;
Calculated MW52kDa
FormulationAvoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.
StorageStore at -20˚C
Application Details
WB 1:500 - 1:1000
Western blot analysis of extracts of Mouse kidney, using PPAR alpha at 1:1000 dilution.
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
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et al,Dietary emulsifier Polysorbate 80-induced lipotoxicity promotes intestinal senescence
, (2025),
PMID:
Yes
