Product Detail
Product NameATF6 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were purified by affinity purification using immunogen.
ApplicationsWB,IHC,IF
Species ReactivityHuman,Mouse,Rat
SpecificityThe antibody detects endogenous level of total ATF6 protein.
Immunogen TypePeptide
Immunogen DescA synthetic peptide of human ATF6.
Target NameATF6
ConjugateUnconjugated
Other NamesATF6; ATF6A; Activatingtranscriptionfactor6alpha;
Accession NoSwiss-Prot:P18850
NCBI Gene ID:22926
Uniprot
P18850
Gene ID
22926;
Sdspage MW75KD
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20˚C
Application Details
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:100
Western blot analysis of extracts of various cell lines, using ATF6 at 1:1000 dilution.
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
If you have published an article using product 32008, please notify us so that we can cite your literature.
et al,Pharmacologic ATF6 activation confers global protection In widespread disease models by reprogramIng cellular proteostasis. In Nat Commun on 2019 Jan 14 by Blackwood EA, Azizi K, et al.. PMID:30643122
, (2019),
PMID:
30643122
et al,Magnesium Isoglycyrrhizinate Promotes the Activated Hepatic Stellate Cells Apoptosis via Endoplasmic Reticulum Stress and Ameliorates Fibrogenesis in Vitro and in Vivo.In Biofactors on 2017 Nov by Mianli Bian , Xingran Chen,et al..PMID: 29048780
, (2017),
PMID:
29048780
et al,Quercetin Stimulates Mitochondrial Apoptosis Dependent on Activation of Endoplasmic Reticulum Stress in Hepatic Stellate Cells .In Pharm Biol. On 2016 Dec by Liwei He , Xianbang Hou et al..PMID:27572285
, (2016),
PMID:
27572285
et al,5鈥慛itro锟?锟?3鈥憄henylpropylamino) benzoic acid induces apoptosis of human lens epithelial cells via reactive oxygen species and endoplasmic reticulum stress through the mitochondrial apoptosis pathway. In Int J Mol Med on 2021 Apr by Lingzhi Niu, Xin Liu,et al..PMID:33604681
, (2021),
PMID:
33604681
et al,ATF6 aggravates angiogenesis-osteogenesis coupling during ankylosing spondylitis by mediating FGF2 expression in chondrocytes. In iScience on 2021 Jun 28 by Mengjun Ma,
Hongyu Li,et al..PMID:34296071
, (2021),
PMID:
34296071
et al,Artemisinin alleviates astrocyte overactivation and neuroinflammation by modulating the IRE1/NF-κB signaling pathway in in vitro and in vivo Alzheimer's disease models.
, (2025),
PMID:
39826816
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