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Location： Home > Polyclonal Antibodies > HMGCR Antibody

HMGCR Antibody#32356

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Product Detail

Product NameHMGCR Antibody

Host SpeciesRabbit

ClonalityPolyclonal

IsotypeIgG

PurificationThe antibody was purified by immunogen affinity chromatography.

ApplicationsWB;IHC

Species ReactivityHuman,Mouse,Rat

SpecificityThe antibody detects endogenous level of total HMGCR protein.

Immunogen TypeRecombinant Protein

Immunogen DescRecombinant fusion protein of human HMGCR (NP_000850.1).

Target NameHMGCR

ConjugateUnconjugated

Other NamesHMGCR;LDLCQ3;HMGCR

Accession NoUniprot:P04035
GeneID:3156

Uniprot P04035

Gene ID 3156

Sdspage MW97KDa

Concentration1.0mg/ml

FormulationLiquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

StorageStore at -20˚C. Avoid freeze / thaw cycles.

Application Details
WB 1:500-1:1000;
IHC 1:50-1:100;
Western blot analysis of HMGCR expression in HepG2 (A), Hela(B), mouse spleen (C), rat liver (D) whole cell lysates.
Western blot analysis of HMGCR expression in HepG2 (A), Hela(B), mouse spleen (C), rat liver (D) whole cell lysates.
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

If you have published an article using product 32356, please notify us so that we can cite your literature.

et al,Diaporisoindole B Reduces Lipid Accumulation in THP-1 Macrophage Cells via MAPKs and PPARγ-LXRα Pathways and Promotes the Reverse Cholesterol Transport by Upregulating SR-B1 and LDLR in HepG2 Cells. In J Nat Prod on 2022 Dec 23 by Hongju Liu, Huiyi Xie, et al..PMID:36399085 , (2022),
PMID: 36399085
et al,Cholesterol-lowering effects of rhubarb free anthraquinones and their mechanism of action. In Eur J Pharmacol on 2024 Mar 5 by Lifang Wang, Haijiao Wang,et al..PMID:38286356 , (2024),
PMID: 38286356

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

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