Product Detail
                                
                                                                        Product NameGPX4 Antibody
                                                                                 Host SpeciesRabbit
                                         ClonalityPolyclonal
                                        IsotypeIgG
                                        PurificationAffinity purification
                                        ApplicationsWB,IHC,IF
                                        Species ReactivityHuman,Mouse,Rat
                                        SpecificityThe antibody detects endogenous level of total GPX4 protein.
                                        Immunogen TypeRecombinant Protein
                                         Immunogen DescRecombinant fusion protein of human GPX4 (NP_002076.2).
                                         Target NameGPX4
                                         ConjugateUnconjugated
                                                                                 Other NamesGPX4;GPx-4;GSHPx-4;MCSP;PHGPx;SMDS;snGPx;snPHGPx
                                        Accession NoUniprot:P36969
GeneID:2879
                                        Uniprot
                                        P36969
                                        
                                        Gene ID
                                        2879
                                        
                                                                                Sdspage MW22KDa
                                        Concentration1.0mg/ml
                                         FormulationPBS with 0.02% sodium azide,50% glycerol,pH7.3.
                                        StorageStore at -20˚C. Avoid freeze / thaw cycles.
                                                                                                                                                         
                                Application Details
                                WB	1:500 - 1:2000
IHC	1:50 - 1:200
IF	1:50 - 1:200
                             
                            
                                                                
                                    
                                    Immunohistochemistry of paraffin-embedded rat testis using GPX4 Rabbit pAb.
                                 
                                                                
                                    
                                    Western blot analysis of extracts of various cell lines, using GPX4 antibody.
                                 
                                                                
                                    
                                    Immunofluorescence analysis of L929 cells using GPX4 Rabbit pAb.
                                 
                                                                
                                    
                                    Immunohistochemistry of paraffin-embedded mouse testis using GPX4 Rabbit pAb.
                                 
                                                                
                                    
                                    Immunofluorescence analysis of C6 cells using GPX4 Rabbit pAb.
                                 
                                                                
                                    
                                    Immunohistochemistry of paraffin-embedded human appendix using GPX4 Rabbit pAb.
                                 
                                                             
                            
                                The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. 
                            
                            
                                If you have published an article using product 32506, please notify us so that we can cite your literature.
                                                                                                    
                                      et al,Heparanase-driven sequential released nanoparticles for ferroptosis and tumor microenvironment modulations synergism in breast cancer therapy. In Biomaterials on 2021 Jan by Jun Zhang, Jie Yang, et al..PMID:33035717
 ,  (2021),
PMID:
                                    33035717 
                                 
                                                                                                                                        
                                      et al,c-Myc protects hepatocellular carcinoma cell from ferroptosis induced by glutamine deprivation via upregulating GOT1 and Nrf2InMol Biol RepOn2023 AugbyYuxiang Zhao?1,?Yue Wang et al..PMID:?37358765
 ,  (2023),
PMID:
                                    37358765 
                                 
                                                                                                                                        
                                      et al,Gingerenone A induces ferroptosis in colorectal cancer via targeting suppression of SLC7A11 signaling pathway. In Biomed Pharmacother on 2024 Nov by Hongyu Xiao, Chen Chen, et al..PMID: 39393329
 ,  (2024),
PMID:
                                    39393329 
                                 
                                                                                                                                        
                                      et al,Classical prescription Daqinjiao decoction inhibit cerebral ischemia/reperfusion induced necroptosis and ferroptosis through multiple mechanisms.
 ,  (2025),
PMID:
                                    39736347 
                                 
                                                                                                                                        
                                      et al,Dictamnine alleviates DSS-induced colitis mice by inhibiting ferroptosis of enterocytes via activating Nrf2-Gpx4 signaling pathway.
 ,  (2025),
PMID:
                                    40049578