Product Detail
Product NameTau (Ab-396) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ApplicationsWB
Species ReactivityHu
SpecificityThe antibody detects endogenous levels of Tau protein around Serine 396.
Immunogen TypePeptide
Immunogen DescSynthesized non-phosphopeptide derived from human Tau around the phosphorylation site of Serine 396.
Target NameTau
ConjugateUnconjugated
Other NamesMAPT; Microtubule-associated protein tau; MTBT1; Neurofibrillary tangle protein; Paired helical filament-tau
Accession NoSwiss-Prot: P10636
NCBI Gene ID: 4137
Uniprot
P10636
Gene ID
4137;
Sdspage MW78kd
Concentration1.0mg/ml
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20˚C
Application Details
Western blotting: 1:500~1:3000
Western blot analysis of extracts from HeLa cells, using Tau (Ab-396) antibody #33207.
Western blot analysis of extracts from 293 cells (Lane 2), using Tau (Ab-396) antiobdy #33207. The lane on the left is treated with synthesized peptide.
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Puig B, et al. (2005) Acta Neuropathol (Berl). 110(3):261-268.
DeGiorgis JA, et al. (2005) J Proteome Res. 4(2): 306-315.
Alonso Adel C, et al. (2004) J Biol Chem. 279(33): 34873-34881.
If you have published an article using product 33207, please notify us so that we can cite your literature.
et al,Fingolimod ameliorates amyloid deposition and neurodegeneration in APP/PS1 mouse model of Alzheimer's disease.
, (2025),
PMID:
40158900
Yes
