Product Detail
Product NameNRF2 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ApplicationsWB IHC IF
Species ReactivityHu Ms Rt
SpecificityThe antibody detects endogenous levels of total NRF2 protein.
Immunogen TypePeptide
Immunogen DescSynthesized peptide derived from human NRF2.
Target NameNRF2
ConjugateUnconjugated
Other NamesHEBP1; NF-E2 related factor 2; NF2L2; NFE2-related factor 2; NFE2L2
Accession NoSwiss-Prot: Q16236
NCBI Gene ID: 4780
Uniprot
Q16236
Gene ID
4780;
Sdspage MW68kd
Concentration1.0mg/ml
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20˚C
Application Details
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500
Western blot analysis of extracts from HuvEc cells, using NRF2 antibody #33450.
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using NRF2 antibody #33450.
Immunofluorescence analysis of HuvEc cells, using NRF2 antibody #33450.
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Rajesh K. Thimmulappa, J. Clin. Invest., Apr 2006; 116: 984 - 995.
Sara B. Cullinan, Mol. Cell. Biol., Oct 2003; 23: 7198 - 7209.
Tirumalai Rangasamy, J. Exp. Med., Jul 2005; 202: 47 - 59.
Wenge Li, J. Biol. Chem., Aug 2005; 280: 28430 - 28438.
If you have published an article using product 33450, please notify us so that we can cite your literature.
et al,Artemisinin protected human bronchial epithelial cells from amiodarone-induced oxidative damage via 5'-AMP-activated protein kinase (AMPK) activation.
, (2025),
PMID:
39803706
Yes
