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Location： Home > Polyclonal Antibodies > TLR4 Antibody

TLR4 Antibody#35463

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Product Detail

Product NameTLR4 Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntibodies were purified by antigen-affinity chromatography.

ApplicationsWB IHC

Species ReactivityHu Ms Rt

SpecificityThe antibody detects endogenous levels of total TLR4 protein.

Immunogen TypeRecombinant Protein

Immunogen DescA synthesized peptide derived from human TLR4

Target NameTLR4

ConjugateUnconjugated

Other NamesARMD10 antibody; CD284 antibody; TOLL antibody; hToll antibody; TLR4 antibody; homolog of Drosophila toll antibody; toll-like receptor 4 antibody

Accession NoSwiss-Prot#:O00206;
NCBI Gene#:7099

Uniprot O00206

Gene ID 7099;

Sdspage MW96kd

Concentration1mg/ml

FormulationRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

StorageStore at -20˚C

Application Details

Western blotting: 1:500-1:2000
Immunofluorescence: 1:50-1:200

Western blot analysis of TLR4 expression in Hela whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
Immunohistochemical analysis of paraffin-embedded human prostate tissue using TLR4 Antibody

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq]

If you have published an article using product 35463, please notify us so that we can cite your literature.

et al,Prevention of acute kidney injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression.In J Hepatol on 2012 May by Shah N, Dhar D, et al..PMID:22266601 , (2012),
PMID: 22266601
et al,Vanillin Attenuates Proinflammatory Factors in a tMCAO Mouse Model via Inhibition of TLR4/NF-kB Signaling Pathway. In Neuroscience on 2022 May 21 by Ping Wang, Chunyi Li, et al..PMID: 35276304 , (2022),
PMID: 35276304
et al,Cannabidiol attenuates periodontal inflammation through inhibiting TLR4/NF-κB pathwayInJ Periodontal ResOn2023 AugbyHao Chen?1,?Yaqi Liu et al..PMID:?37143211 , (2023),
PMID: 37143211
et al,Small molecule inhibitor CRT0066101 inhibits cytokine storm syndrome in a mouse model of lung injury In Int ImmunopharmacolOn2023 JulbyBomiao Cui , Yiying Liu et al..PMID:37182445 , (2023),
PMID: 37182445
et al,β-Sitosterol Alleviates Neuropathic Pain by Affect Microglia Polarization through Inhibiting TLR4/NF-κB Signaling PathwayInJ Neuroimmune PharmacolOn2023 DecbyYachun Zheng , Jiaji Zhao et al..PMID:38041701 , (2023),
PMID: 38041701
et al,Prevotella copri promotes vascular calcification via lipopolysaccharide through activation of NF-κB signaling pathway. In Gut Microbes on 2024 Jan-Dec by Qing-Yun Hao, Jing Yan, et al..PMID:38727248 , (2024),
PMID: 38727248
et al,Prevotella copri promotes vascular calcification via lipopolysaccharide through activation of NF-κB signaling pathway , (2024),
PMID:

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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