Product Detail
Product NameWnt1 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were purified by antigen-affinity chromatography.
ApplicationsWB
Species ReactivityHu
SpecificityThe antibody detects endogenous levels of total Wnt1 protein.
Immunogen TypeRecombinant Protein
Immunogen DescRecombinant fragment corresponding to a region within amino acids 1 and 234 of WNT1.
Target NameWnt1
ConjugateUnconjugated
Other NamesINT1 antibody; WNT1 antibody; proto-oncogene Wnt-1 antibody; wingless-type MMTV integration site family; member 1 (oncogene INT1) antibody; proto-oncogene Int-1 homolog antibody; wingless-type MMTV integration site family; member 1 antibody
Accession NoSwiss-Prot#:P04628;
NCBI Gene#:7471
Uniprot
P04628
Gene ID
7471;
Sdspage MW41kd
Concentration1mg/ml
FormulationRabbit IgG in 1XPBS, 1%BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
StorageStore at -20˚C
Application Details
Western blotting: 1:500-1:3000
Wnt1 antibody detects Wnt1 protein by Western blot analysis.
A. 30 μg 293T whole cell lysate/extract
B. 30 μg whole cell lysate/extract of human WNT1-transfected 293T cells
10% SDS PAGE
#35481 diluted at 1:1000
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq]
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et al,Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice
, (2024),
PMID:
Yes
