Product Detail
Product NameAIM2 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntigen affinity purification.
ApplicationsIHC
Species ReactivityHu
SpecificityThe antibody detects endogenous levels of total AIM2 protein.
Immunogen TypeRecombinant Protein
Immunogen DescFusion protein corresponding to a region derived from internal residues of human absent in melanoma 2
Target NameAIM2
ConjugateUnconjugated
Other NamesPYHIN4
Accession NoSwiss-Prot#: O14862
NCBI Gene ID: 9447
Gene Accssion: BC010940
Uniprot
O14862
Gene ID
9447;
Concentration3.4mg/ml
FormulationRabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
StorageStore at -20˚C
Application Details
Immunohistochemistry: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #36253 at dilution 1/60.
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using #36253 at dilution 1/60.
Interferon-inducible protein AIM2 (Absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-?, AIM2 is thought to act as a tumor suppressor by repressing NF?B transcriptional activity. Localized to the nucleus, AIM2 contains one DAPIN domain and one HIN-200 domain. The DAPIN domain is composed mostly of ?-helixes and is a protein-protein interaction domain capable of binding other DAPIN domains. The HIN-200 domain has been shown to bind directly to DNA, which, along with the binding of another protein ASC, results in the activation of Caspase-1.?
If you have published an article using product 36253, please notify us so that we can cite your literature.
et al,Pan-cancer analysis of AIM2 inflammasomes with potential implications for immunotherapy in human cancer: A bulk omics research and single cell sequencing validation.. In Front Immunol on 2022 Sep 29 by Yan Qin, Liuxian Pan,et al..PMID: 36248785
, (2022),
PMID:
36248785
Yes
