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SETD7 Antibody#36520

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Product Detail

Product NameSETD7 Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntigen affinity purification.

ApplicationsIHC WB

Species ReactivityHu

SpecificityThe antibody detects endogenous levels of total SETD7 protein.

Immunogen TypeRecombinant Protein

Immunogen DescFusion protein corresponding to residues near the C terminal of human SET domain containing (lysine methyltransferase) 7

Target NameSETD7

ConjugateUnconjugated

Other NamesKMT7; SET7; SET9; SET7/9

Accession NoSwiss-Prot#: Q8WTS6
NCBI Gene ID: 80854
Gene Accssion: BC121055

Uniprot Q8WTS6

Gene ID 80854;

Concentration0.9mg/ml

FormulationRabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

StorageStore at -20˚C

Application Details

Immunohistochemistry: 1:50-1:200
Western blotting: 1:500-1000

Immunohistochemical analysis of paraffin-embedded Human tonsil cancer tissue using #36520 at dilution 1/20.
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using #36520 at dilution 1/20.
Western blotting analysis using SETD7 Antibody #36520.

The methylation of histones plays a pivotal role in the regulation of chromatin structure and gene expression. Histone methylation can occur on Arg or Lys residues, with an exquisite site selectivity for Lys methylation at specific positions in the N-termini of histones H3 and H4. SET7/9, a histone methyltransferase (HMTase), which transfers methyl groups to Lys4 of histone H3, forms a complex with S-adenosyl-L-methionine. This complex contains an active site consisting of a binding pocket where an AdoMet molecule in an unusual conformation binds, a narrow substrate-specific channel that only unmethylated lysine residues can access and a catalytic tyrosine residue.

If you have published an article using product 36520, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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