Product Detail
Product NameINSIG2 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntigen affinity purification.
ApplicationsIHC
Species ReactivityHu
SpecificityThe antibody detects endogenous levels of total INSIG2 protein.
Immunogen TypeRecombinant Protein
Immunogen DescFusion protein corresponding to a region derived from internal residues of human insulin induced gene 2
Target NameINSIG2
ConjugateUnconjugated
Other NamesINSI2;INSIG2 membrane protein; insulin induced protein 2
Accession NoSwiss-Prot#: Q9Y5U4
NCBI Gene ID: 51141
Gene Accssion: BC022475
Uniprot
Q9Y5U4
Gene ID
51141;
Concentration1.4mg/ml
FormulationRabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
StorageStore at -20˚C
Application Details
Immunohistochemistry: 1:25-1:100
Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using #36556 at dilution 1/30.
Immunohistochemical analysis of paraffin-embedded Human brain tissue using #36556 at dilution 1/30.
The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.
If you have published an article using product 36556, please notify us so that we can cite your literature.
et al,The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis
, (2020),
PMID:
32322062
Yes
