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FGF2 Antibody#36769

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Product Detail

Product NameFGF2 Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntigen affinity purification.

ApplicationsWB IHC

Species ReactivityHu Ms Rt

SpecificityThe antibody detects endogenous levels of total FGF2 protein.

Immunogen TypePeptide

Immunogen DescSynthetic peptide corresponding to a region derived from internal residues of human Fibroblast growth factor 2

Target NameFGF2

ConjugateUnconjugated

Other NamesBFGF; FGFB; FGF-2; HBGF-2

Accession NoSwiss-Prot#: P09038
NCBI Gene ID: 2247
Gene Accssion: NP_001997

Uniprot P09038

Gene ID 2247;

Sdspage MW31kd

Concentration1mg/ml

FormulationRabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

StorageStore at -20˚C

Application Details

Western blotting: 1:1000-1:5000
Immunohistochemistry: 1:100-1:500

Gel: 8%SDS-PAGE
Lysates (from left to right): Mouse lung tissue
Amount of lysate: 30ug per lane
Primary antibody: 1/1000 dilution
Secondary antibody dilution: 1/8000
Exposure time: 10 seconds
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using #36769 at dilution 1/100.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.

If you have published an article using product 36769, please notify us so that we can cite your literature.

et al,Growth of MCF-7 breast cancer cells and efficacy of anti-angiogenic agents in a hydroxyethyl chitosan/glycidyl methacrylate hydrogel.In Cancer Cell Int on 2017 May 16 by Hejing Wang,Junmin Qian,et al..PMID: 28515673 , (2017),
PMID: 28515673
et al,Apurinic/apyrimidinic endonuclease 1 induced upregulation of fibroblast growth factor 2 and its receptor 3 induces angiogenesis in human osteosarcoma cells.In Cancer Sci on 2014 Feb by Tao Ren, Yi Qing et al..PMID:24329908 , (2014),
PMID: 24329908
et al,ATF6 aggravates angiogenesis-osteogenesis coupling during ankylosing spondylitis by mediating FGF2 expression in chondrocytes. In iScience on 2021 Jun 28 by Mengjun Ma, Hongyu Li,et al..PMID:34296071 , (2021),
PMID: 34296071
et al,Exosomal miR-100-5p inhibits osteogenesis of hBMSCs and angiogenesis of HUVECs by suppressing the BMPR2/Smad1/5/9 signalling pathway. , (2021),
PMID: 34256859

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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