Product Detail
Product NameCTLA4 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntigen affinity purification.
ApplicationsIHC
Species ReactivityHu Ms
SpecificityThe antibody detects endogenous levels of total CTLA4 protein.
Immunogen TypePeptide
Immunogen DescSynthetic peptide corresponding to residues near the C terminal of human Cytotoxic T-lymphocyte protein 4
Target NameCTLA4
ConjugateUnconjugated
Other NamesCD; GSE; GRD4; ICOS; CD152; CTLA-4; IDDM12; CELIAC3
Accession NoSwiss-Prot#: P16410
NCBI Gene ID: 1493
Gene Accssion: NP_005205
Uniprot
P16410
Gene ID
1493;
Concentration0.8mg/ml
FormulationRabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
StorageStore at -20˚C
Application Details
Immunohistochemistry: 1:25-1:100
Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using #36808 at dilution 1/25.
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
If you have published an article using product 36808, please notify us so that we can cite your literature.
et al,SLC35A2 expression drives breast cancer progression via ERK pathway activation
, (2023),
PMID:
Yes
