Product Detail
Product NameCK19 Mouse Monoclonal Antibody
Clone No.11F5
Host SpeciesMouse
ClonalityMonoclonal
PurificationAffinity purification using immunogen.
ApplicationsIHC
Species ReactivityHu Ms Rt
SpecificityThe CK19 Mouse Monoclonal antibody detects endogenous CK19 proteins.
Target NameCK19
ConjugateUnconjugated
Other Names40-kDa keratin intermediate filament; CK-19; CK19; cytokeratin 19; Cytokeratin-19; K19
Accession NoSwiss-Prot#:P08727
Uniprot
P08727
Gene ID
3880;
Sdspage MW44kd
Concentration1.0mg/ml
FormulationMouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20˚C
Application Details
Immunohistochemistry: 1:200
IHC staining of paraffin-embedded Human colon cancer tissue with CK19 mouse mAb(11F5) diluted at 1:200.
Ck19 protein is a member of the keratin family. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Keratin 19 is not expressed in hepatocytes, therefore, antibody to keratin 19 is useful in the identification of liver metastasis. The degree of keratin 19 positivity in breast cancer distinguishes malignant from benign tumours. Keratin 19 is often co-expressed with keratin 7.
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