Product Detail
Product NameDCX antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were purified by affinity purification using immunogen.
ApplicationsWB,IF
Species ReactivityHuman,Mouse,Rat
SpecificityThe antibody detects endogenous level of total DCX protein.
Immunogen TypeRecombinant Protein
Immunogen DescRecombinant protein of human DCX.
Target NameDCX
ConjugateUnconjugated
Other NamesDCX;DBCN;DC;LISX;SCLH;XLIS;
Accession NoSwiss-Prot#: O43602
NCBI Gene ID: 1641
Uniprot
O43602
Gene ID
1641;
Sdspage MW45kd
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20˚C
Application Details
WB 1:500 - 1:2000
IF 1:50 - 1:200
Western blot analysis of extracts of mouse brain, using DCX .
Mutations in Doublecortin cause Lissencephaly (smooth brain), a neuronal migration disorder characterized by epilepsy and mental retardation (1). Doublecortin is a microtubule associated protein that stabilizes and bundles microtubules. A conserved doublecortin domain mediates the interaction with microtubules, and interestingly most missense mutations cluster in this domain (2). Kinases JNK, CDK5 and PKA phosphorylate doublecortin. JNK phosphorylates Thr321, Thr331 and Ser334 while PKA phosphorylates Ser47 and CDK5 phosphorylates Ser297 (3-5). Phosphorylation of Ser297 lowers the affinity of doublecortin to microtubules. Furthermore, mutations of Ser297 result in migration defects (5).
If you have published an article using product 38200, please notify us so that we can cite your literature.
et al,Naoxinqing tablet protects against cerebral ischemic/reperfusion injury by regulating ampkα/NAMPT/SIRT1/PGC-1α pathwayInJ EthnopharmacolOn2024 Mar 25byXiao Sun?1,?Yunfeng Pan et al..PMID:?38159826
, (2023),
PMID:
38159826
et al,Naoxinqing tablet protects against cerebral ischemic/reperfusion injury by regulating ampkα/NAMPT/SIRT1/PGC-1α pathway. In J Ethnopharmacol on 2024 Mar 25 by Xiao Sun, Yunfeng Pan,et al..PMID:38159826
, (2024),
PMID:
38159826
The lead time is currently 2 weeks.
