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INS antibody#38355

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Product Detail

Product NameINS antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntibodies were purified by affinity purification using immunogen.

ApplicationsWB,IHC,IF

Species ReactivityHuman,Mouse,Rat

SpecificityThe antibody detects endogenous level of total INS protein.

Immunogen TypeRecombinant Protein

Immunogen DescRecombinant protein of human INS.

Target NameINS

ConjugateUnconjugated

Other NamesILPR; IRDN; IDDM2; MODY10; Insulin;

Accession NoSwiss-Prot#: P01308
NCBI Gene ID: 3630

Uniprot P01308

Gene ID 3630;

Sdspage MW12kd

Concentration1.0mg/ml

FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

StorageStore at -20˚C

Application Details
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Immunofluorescence analysis of rat pancreas using INS at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of mouse pancreas using INS at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded rat pancreatic islet using INS at dilution of 1:50 (40x lens).
Immunohistochemistry of paraffin-embedded mouse pancreatic islet using INS at dilution of 1:50 (40x lens).
Western blot analysis of extracts of mouse pancreas, using INS at 1:1000 dilution.

The maintenance of glucose homeostasis is an essential physiological process that is regulated by hormones. An elevation in blood glucose levels during feeding stimulates insulin release from pancreatic β cells through a glucose sensing pathway (1). Insulin is synthesized as a precursor molecule, proinsulin, which is processed prior to secretion. A- and B-peptides are joined together by a disulfide bond to form insulin, while the central portion of the precursor molecule is cleaved and released as the C-peptide. Insulin stimulates glucose uptake from blood into skeletal muscle and adipose tissue. Insulin deficiency leads to type 1 diabetes mellitus (2).

If you have published an article using product 38355, please notify us so that we can cite your literature.

et al,Clinical and functional characterization of a novel KCNJ11 (c. 101G> A, p. R34H) mutation associated with maturity-onset diabetes mellitus of the young type 13. In Endocrine on 2024 Nov by Xiaoyu Lv, Jing Gao,et al..PMID:38761346 , (2024),
PMID: 38761346
et al,Clinical and functional characterization of a novel KCNJ11 (c.101G > A, p.R34H) mutation associated with maturity-onset diabetes mellitus of the young type 13 , (2024),
PMID:

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

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