Product Detail
Product NameCSF1R antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB,IF
Species ReactivityHuman,Mouse,Rat
SpecificityThe antibody detects endogenous level of total CSF1R protein.
Immunogen TypePeptide
Immunogen DescA synthetic peptide of human CSF1R
Target NameCSF1R
ConjugateUnconjugated
Other NamesCSF1R;C-FMS;CD115;CSF-1R;CSFR;FIM2;FMS;HDLS;M-CSF-R;BANDDOS
Accession NoUniprot:P07333
GeneID:1436
Uniprot
P07333
Gene ID
1436
Sdspage MW150-190KDa
Concentration1.0mg/ml
FormulationPBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.
Application Details
WB 1:500 - 1:2000
IF 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using CSF1R antibody.
Immunofluorescence analysis of mouse bone marrow cells using CSF1R Rabbit pAb.
Immunofluorescence analysis of THP-1 cells using CSF1R Rabbit pAb.
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma.
If you have published an article using product 38540, please notify us so that we can cite your literature.
et al,Stigmasterol alleviates neuropathic pain by reducing Schwann cell‐macrophage cascade in DRG by modulating IL‐34/CSF1R. In CNS Neurosci Ther on 2024 Apr by Waimei Si, Zhenni Chen, et al..PMID:38572785
, (2024),
PMID:
38572785
The lead time is currently 2 weeks.
