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NLRP3 antibody#38679

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Product Detail

Product NameNLRP3 antibody

Host SpeciesRabbit

ClonalityPolyclonal

IsotypeIgG

PurificationAffinity purification

ApplicationsWB

Species ReactivityMouse,Rat

SpecificityThe antibody detects endogenous level of total NLRP3 protein.

Immunogen TypeRecombinant Protein

Immunogen DescRecombinant protein of human NLRP3

Target NameNLRP3

ConjugateUnconjugated

Other NamesNLRP3;AGTAVPRL;AII;AVP;C1orf7;CIAS1;CLR1.1;FCAS;FCAS1;FCU;MWS;NALP3;PYPAF1

Accession NoUniprot:Q96P20
GeneID:114548

Uniprot Q96P20

Gene ID 114548

Sdspage MW110KDa

Concentration1.0mg/ml

FormulationPBS with 0.02% sodium azide,50% glycerol,pH7.3.

StorageStore at -20˚C. Avoid freeze / thaw cycles.

Application Details

WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200

Western blot analysis of extracts of 293T cells, using NLRP3 antibody.
Western blot analysis of extracts of Rat lung, using NLRP3 antibody.
Immunohistochemistry of paraffin-embedded human liver cancer using NLRP3 antibody.
Immunohistochemistry of paraffin-embedded mouse liver using NLRP3 antibody.
Immunohistochemistry of paraffin-embedded rat lung using NLRP3 antibody.
Immunofluorescence analysis of U2OS cells using NLRP3 antibody.
Immunofluorescence analysis of NIH/3T3 cells using NLRP3 antibody.
Immunofluorescence analysis of THP-1 cells using NLRP3 antibody.
Immunofluorescence analysis of PC-12 cells using NLRP3 antibody.
Immunofluorescence analysis of RAW264.7 cells using NLRP3 antibody.

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

If you have published an article using product 38679, please notify us so that we can cite your literature.

et al,5-(3,4-Difluorophenyl)-3-(6-methylpyridIn-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targetIng braIn tissue, protects agaInst MPTP-Induced subacute ParkInson's disease in mice by InhibitIng the NLRP3 Inflammasome and protects PC12 cells agaInst oxidative stress. In Free Radic Biol Med on 2019 Jan 5 by Xu LL, Wu YF, et al..PMID:30615919 , (2019),
PMID: 30615919
et al,Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice. In Pharmacol Res on 2020 May by Yanyan Zhu, Chenhui Zhu, et al..PMID: 32156650 , (2020),
PMID: 32156650
et al,Aurantio-obtusin Alleviates Dry Eye Disease by Targeting NF-κB/NLRP3 Signaling in Rodent Models , (2023),
PMID:
et al,Adenosine A1 receptor agonist alleviates cerebral ischemia/reperfusion injury by inhibiting Nrf2/NLRP3 signaling‑mediated pyroptosis. , (2025),
PMID: 40162050

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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