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DMP1 antibody#38779

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Product Detail

Product NameDMP1 antibody

Host SpeciesRabbit

ClonalityPolyclonal

IsotypeIgG

PurificationAffinity purification

ApplicationsWB,IHC

Species ReactivityHuman,Mouse,Rat

SpecificityThe antibody detects endogenous level of DMP1 protein.

Immunogen TypeRecombinant Protein

Immunogen DescRecombinant fusion protein of human DMP1 (NP_004398.1).

Target NameDMP1

ConjugateUnconjugated

Other NamesDMP1;ARHP;ARHR;DMP-1

Accession NoUniprot:Q13316
GeneID:1758

Uniprot Q13316

Gene ID 1758

Calculated MWPredicted band size: 54; 55 kD; Observed band size: 102 kD

Sdspage MW56kd

Concentration1.0mg/ml

FormulationLiquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

StorageStore at -20˚C. Avoid freeze / thaw cycles.

Application Details

WB 1/500 - 1/1000 IHC 1:50-1:100

Western blot analysis of DMP1 expression in U251 (A), mouse brain (B), rat brain (C) whole cell lysates.
Immunohistochemical analysis of DMP1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. Tyramide-AF488 (green) was used as the chromogen. The section was then counterstained with DAPI (blue).

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.

If you have published an article using product 38779, please notify us so that we can cite your literature.

et al,KPNB1-ATF4 induces BNIP3-dependent mitophagy to drive odontoblastic differentiation in dental pulp stem cells. In Cell Mol Biol Lett on 2024 Nov 27 by Zeying Zhang, Di Yang,et al..PMID:39604846 , (2024),
PMID: 39604846

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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