Product Detail
Product NamePSMD12 antibody
Host SpeciesRabbit
ClonalityPolyclonal
IsotypeIgG
PurificationAffinity purification
ApplicationsWB
Species ReactivityHuman,Mouse,Rat
SpecificityThe antibody detects endogenous level of total PSMD12 protein.
Immunogen TypeRecombinant Protein
Immunogen DescRecombinant fusion protein of human PSMD12 (NP_002807.1).
Target NamePSMD12
ConjugateUnconjugated
Other NamesPSMD12;Rpn5;p55;STISS
Accession NoUniprot:O00232
GeneID:5718
Uniprot
O00232
Gene ID
5718
Sdspage MW53kDa
Concentration1.0mg/ml
FormulationPBS with 0.02% sodium azide,50% glycerol,pH7.3.
StorageStore at -20˚C. Avoid freeze / thaw cycles.
Application Details
WB 1:500 - 1:2000
Western blot analysis of extracts of various cell lines, using PSMD12 antibody.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
If you have published an article using product 39119, please notify us so that we can cite your literature.
et al,NSP6 inhibits the production of ACE2-containing exosomes to promote SARS-CoV-2 infectivity. In mBio on 2024 Mar 13 by Xi Lv, Ran Chen,et al..PMID:38303107
, (2024),
PMID:
38303107
The lead time is currently 2 weeks.
