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chromogranin A Monoclonal Antibody#42019

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Product Detail

Product Namechromogranin A Monoclonal Antibody

Host SpeciesMouse

ClonalityMonoclonal

Purificationprotein G purifed

ApplicationsWB IHC

Species ReactivityHu

Specificityspecific for Recombinant CHGA Protein denatured and native forms

Immunogen Typeprotein

Immunogen DescRecombinant CHGA Protein

Target Namechromogranin A

ConjugateUnconjugated

Other NamesChromogranin-A, CgA, Pituitary secretory protein I, SP-I, Vasostatin II, CHGA

Accession NoSwiss-Prot#: P10645

Uniprot P10645

Gene ID 1113;

Calculated MW52kd

Concentration1.0mg/mL

FormulationPreservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

StorageStore at -20˚C

Application Details
Western blotting: 1:500 - 1:1000
Immunohistochemistry: 1:20 - 1:200
All lanes : Chromogranin-A transfected E.coli lysate Line 1:Mouse Anti--6*his monoclonal antibody at 1ug/m Line2 : Mouse anti- Chromogranin-A monoclonal antibody at ug/ml Predicted band size : 52Kd Observed band size : 52kd
Immunohistochemical analysis of paraffin-embedded Human small intestine tissue using #42019 at dilution of 1:200.
Immunohistochemical analysis of paraffin-embedded Human pancreas tissue using #42019 at dilution of 1:200.
Chromogranin A is a member of the granin family of neuroendocrine secretory proteins. It is located in secretory vesicles of neurons and endocrine cells. Chromogranin A is the precursor to several functional peptides including vasostatin, pancreastatin, catestatin and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine). CgA is one of the most used tumor markers in NET's (neuroendocrine tumors) , and elevated CgA concentrations have been demonstrated in serum or plasma of patients with different types of these tumors. However, CgA is not a tumor-specific antigen for NETs, and an abnormal concentration has been described in some non-malignant diseases such as renal failure, heart failure, proton pump inhibition, gastritis, hypertension, or patients with liver diseases.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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